Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts.

TitleElectronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts.
Publication TypePublication
Year2017
AuthorsBowler RP, Hansel NN, Jacobson S, R Barr G, Make BJ, Han MK, O'Neal WK, Oelsner EC, Casaburi R, Barjaktarevic I, Cooper C, Foreman M, Wise RA, DeMeo DL, Silverman EK, Bailey W, Harrington KF, Woodruff PG, M Drummond B
Corporate Authorsfor COPDGene and SPIROMICS Investigators
JournalJ Gen Intern Med
Volume32
Issue12
Pagination1315-1322
Date Published2017 Dec
ISSN1525-1497
KeywordsAdult, Aged, Aged, 80 and over, Bronchitis, Cigarette Smoking, Cohort Studies, Disease Progression, Electronic Nicotine Delivery Systems, Female, Harm Reduction, Humans, Longitudinal Studies, Male, Middle Aged, Prevalence, Pulmonary Disease, Chronic Obstructive, Severity of Illness Index, Smoking Cessation, Tobacco Use Disorder, United States, Vaping
Abstract

BACKGROUND: Electronic cigarettes (e-cigarettes) are battery-operated nicotine-delivery devices used by some smokers as a cessation tool as well as by never smokers.OBJECTIVE: To determine the usage of e-cigarettes in older adults at risk for or with chronic obstructive pulmonary disease (COPD).DESIGN: Prospective cohorts.PARTICIPANTS: COPDGene (N = 3536) and SPIROMICS (N = 1060) subjects who were current or former smokers aged 45-80.MAIN MEASURES: Participants were surveyed to determine whether e-cigarette use was associated with longitudinal changes in COPD progression or smoking habits.KEY RESULTS: From 2010 to 2016, participants who had ever used e-cigarettes steadily increased to 12-16%, but from 2014 to 2016 current use was stable at ~5%. E-cigarette use in African-Americans (AA) and whites was similar; however, AA were 1.8-2.9 times as likely to use menthol-flavored e-cigarettes. Current e-cigarette and conventional cigarette users had higher nicotine dependence and consumed more nicotine than those who smoked only conventional cigarettes. E-cigarette users had a heavier conventional cigarette smoking history and worse respiratory health, were less likely to reduce or quit conventional cigarette smoking, had higher nicotine dependence, and were more likely to report chronic bronchitis and exacerbations. Ever e-cigarette users had more rapid decline in lung function, but this trend did not persist after adjustment for persistent conventional cigarette smoking.CONCLUSIONS: E-cigarette use, which is common in adults with or at risk for COPD, was associated with worse pulmonary-related health outcomes, but not with cessation of smoking conventional cigarettes. Although this was an observational study, we find no evidence supporting the use of e-cigarettes as a harm reduction strategy among current smokers with or at risk for COPD.

DOI10.1007/s11606-017-4150-7
Alternate JournalJ Gen Intern Med
PubMed ID28884423
PubMed Central IDPMC5698219
Grant ListS10 OD018526 / OD / NIH HHS / United States
U01 HL089897 / HL / NHLBI NIH HHS / United States
K24 HL137013 / HL / NHLBI NIH HHS / United States
U01 HL089856 / HL / NHLBI NIH HHS / United States
U01 HL137880 / HL / NHLBI NIH HHS / United States
K23 HL130627 / HL / NHLBI NIH HHS / United States
MS#: 
MS083
Manuscript Lead/Corresponding Author Affiliation: 
Clinical Center: Denver (National Jewish Health)
ECI: 
Manuscript Status: 
Published and Public