Title | Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS. |
Publication Type | Publication |
Year | 2021 |
Authors | Burkes RM, Couper DJ, Barjaktarevic IZ, Cooper CB, Labaki WW, Han MK, Woodruff PG, Lazarus SC, Parekh TM, Paine R, Comellas AP, Bowler RP, Loehr LR, Putcha N, Wise RA, Brown TT, M Drummond B |
Journal | Chronic Obstr Pulm Dis |
Volume | 8 |
Issue | 2 |
Pagination | 277-291 |
Date Published | 2021 Apr 27 |
ISSN | 2372-952X |
Abstract | INTRODUCTION: Age and vitamin D levels may affect symptom burden in chronic obstructive pulmonary disease (COPD). We used the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) to determine independent associations between vitamin D levels and COPD symptoms in different age strata.METHODS: Serum 25-hydroxy (OH)-vitamin D levels were modeled continuously and categorically (<20 ng/ml versus ≥20 ng/ml). Stratifying by age group (middle-age: 40-64 years old and older: >65 years old), multivariable modeling was performed to identify relationships between 25-OH-vitamin D levels and the COPD Assessment Test (CAT), the modified Medical Research Council score (mMRC), the St George's Respiratory Questionnaire (SGRQ) total and subdomain scores, the Veterans' Specific Activity Questionnaire, and the 6-minute walk test distance.RESULTS: InIn the middle-aged group, each 5 ng/ml higher 25-OH-vitamin D level was independently associated with more favorable CAT score (-0.35 [-0.67 to -0.03], =0.03), total SGRQ (-0.91 [-1.65 to -0.17]; =0.02), and the SGRQ subdomains (Symptoms:-1.07 [-1.96 to -0.18], =0.02; Impact: -0.77 [-1.53 to -0.003], =0.049; Activity: -1.07 [-1.96 to -0.18], =0.02). These associations persisted after the addition of comorbidity score, reported vitamin D supplementation, outdoor time, or season of blood draw to models. No associations were observed between 25-OH-vitamin D levels and symptom scores in the older age group.DISCUSSION: When controlled for clinically relevant covariates, higher 25-OH-vitamin D levels are associated with more favorable respiratory-specific symptoms and quality-of-life assessments in middle-age but not older COPD individuals. Study of the role of vitamin D supplementation in the symptom burden of younger COPD patients is needed. |
DOI | 10.15326/jcopdf.2020.0180 |
Alternate Journal | Chronic Obstr Pulm Dis |
PubMed ID | 33829714 |
PubMed Central ID | PMC8237982 |
Grant List | HHSN268200900013C/ / HB / NHLBI NIH HHS / United States / / Foundation for the NIH / United States P30 ES005605 / ES / NIEHS NIH HHS / United States / / COPD Foundation / United States R01 HL125432 / HL / NHLBI NIH HHS / United States R01HL125432 / HB / NHLBI NIH HHS / United States U24 HL141762 / HL / NHLBI NIH HHS / United States F32HL143867 / HB / NHLBI NIH HHS / United States |
Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.
MS#:
MS158
Manuscript Full Title:
Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.
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Manuscript Status:
Published and Public