Title | Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers. |
Publication Type | Publication |
Year | 2020 |
Authors | Paulin LM, Gassett AJ, Alexis NE, Kirwa K, Kanner RE, Peters S, Krishnan JA, Paine R, Dransfield M, Woodruff PG, Cooper CB, R Barr G, Comellas AP, Pirozzi CS, Han ML, Hoffman EA, Martinez FJ, Woo H, Peng RD, Fawzy A, Putcha N, Breysse PN, Kaufman JD, Hansel NN |
Corporate Authors | for SPIROMICS investigators |
Journal | JAMA Intern Med |
Volume | 180 |
Issue | 1 |
Pagination | 106-115 |
Date Published | 2020 Jan 01 |
ISSN | 2168-6114 |
Keywords | Adult, Aged, Aged, 80 and over, Air Pollution, Cross-Sectional Studies, Disease Progression, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Lung, Male, Middle Aged, Morbidity, Ozone, Pulmonary Emphysema, Retrospective Studies, Risk Assessment, smoking, Tomography, X-Ray Computed, United States |
Abstract | IMPORTANCE: Few studies have investigated the association of long-term ambient ozone exposures with respiratory morbidity among individuals with a heavy smoking history.OBJECTIVE: To investigate the association of historical ozone exposure with risk of chronic obstructive pulmonary disease (COPD), computed tomography (CT) scan measures of respiratory disease, patient-reported outcomes, disease severity, and exacerbations in smokers with or at risk for COPD.DESIGN, SETTING, AND PARTICIPANTS: This multicenter cross-sectional study, conducted from November 1, 2010, to July 31, 2018, obtained data from the Air Pollution Study, an ancillary study of SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study). Data analyzed were from participants enrolled at 7 (New York City, New York; Baltimore, Maryland; Los Angeles, California; Ann Arbor, Michigan; San Francisco, California; Salt Lake City, Utah; and Winston-Salem, North Carolina) of the 12 SPIROMICS clinical sites. Included participants had historical ozone exposure data (n = 1874), were either current or former smokers (≥20 pack-years), were with or without COPD, and were aged 40 to 80 years at baseline. Healthy persons with a smoking history of 1 or more pack-years were excluded from the present analysis.EXPOSURES: The 10-year mean historical ambient ozone concentration at participants' residences estimated by cohort-specific spatiotemporal modeling.MAIN OUTCOMES AND MEASURES: Spirometry-confirmed COPD, chronic bronchitis diagnosis, CT scan measures (emphysema, air trapping, and airway wall thickness), 6-minute walk test, modified Medical Research Council (mMRC) Dyspnea Scale, COPD Assessment Test (CAT), St. George's Respiratory Questionnaire (SGRQ), postbronchodilator forced expiratory volume in the first second of expiration (FEV1) % predicted, and self-report of exacerbations in the 12 months before SPIROMICS enrollment, adjusted for demographics, smoking, and job exposure.RESULTS: A total of 1874 SPIROMICS participants were analyzed (mean [SD] age, 64.5 [8.8] years; 1479 [78.9%] white; and 1013 [54.1%] male). In adjusted analysis, a 5-ppb (parts per billion) increase in ozone concentration was associated with a greater percentage of emphysema (β = 0.94; 95% CI, 0.25-1.64; P = .007) and percentage of air trapping (β = 1.60; 95% CI, 0.16-3.04; P = .03); worse scores for the mMRC Dyspnea Scale (β = 0.10; 95% CI, 0.03-0.17; P = .008), CAT (β = 0.65; 95% CI, 0.05-1.26; P = .04), and SGRQ (β = 1.47; 95% CI, 0.01-2.93; P = .048); lower FEV1% predicted value (β = -2.50; 95% CI, -4.42 to -0.59; P = .01); and higher odds of any exacerbation (odds ratio [OR], 1.37; 95% CI, 1.12-1.66; P = .002) and severe exacerbation (OR, 1.37; 95% CI, 1.07-1.76; P = .01). No association was found between historical ozone exposure and chronic bronchitis, COPD, airway wall thickness, or 6-minute walk test result.CONCLUSIONS AND RELEVANCE: This study found that long-term historical ozone exposure was associated with reduced lung function, greater emphysema and air trapping on CT scan, worse patient-reported outcomes, and increased respiratory exacerbations for individuals with a history of heavy smoking. The association between ozone exposure and adverse respiratory outcomes suggests the need for continued reevaluation of ambient pollution standards that are designed to protect the most vulnerable members of the US population. |
DOI | 10.1001/jamainternmed.2019.5498 |
Alternate Journal | JAMA Intern Med |
PubMed ID | 31816012 |
PubMed Central ID | PMC6902160 |
Grant List | HHSN268200900019C / HL / NHLBI NIH HHS / United States HHSN268200900016C / HL / NHLBI NIH HHS / United States P30 ES005605 / ES / NIEHS NIH HHS / United States HHSN268200900015C / HL / NHLBI NIH HHS / United States U01 HL137880 / HL / NHLBI NIH HHS / United States HHSN268200900013C / HL / NHLBI NIH HHS / United States S10 OD018526 / OD / NIH HHS / United States K23 ES025781 / ES / NIEHS NIH HHS / United States HHSN268200900014C / HL / NHLBI NIH HHS / United States R01 ES023500 / ES / NIEHS NIH HHS / United States K24 HL137013 / HL / NHLBI NIH HHS / United States HHSN268200900020C / HL / NHLBI NIH HHS / United States HHSN268200900017C / HL / NHLBI NIH HHS / United States HHSN268200900018C / HL / NHLBI NIH HHS / United States P30 ES007033 / ES / NIEHS NIH HHS / United States |
Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers.
MS#:
MS121
Manuscript Full Title:
Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers.
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Manuscript Status:
Published and Public